RecruitingNot ApplicableNCT07019519

POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS


Sponsor

University of Copenhagen

Enrollment

30 participants

Start Date

Mar 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying CCK agonist, GIPR antagonist, and others for people with healthy and postural orthostatic tachycardia syndrome (pots). The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 50 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSaline/Placebo

NaCl(9mg/ml)

OTHERGIPR antagonist

GIP(3-30)NH2

OTHERGLP-1R antagonist

GLP-1(9-39)NH2

OTHERCCK agonist

CCK-8


Locations(1)

Rigshospitalet

Copenhagen, Denmark

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NCT07019519


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