RecruitingPhase 4NCT07023003

Postpartum Evaluation of Nifedipine and Enalapril for Hypertension

Postpartum Evaluation of Antihypertensives for Control of Hypertension: A Randomized Controlled Equivalence Study


Sponsor

Nebraska Methodist Health System

Enrollment

850 participants

Start Date

Jul 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is an open label, randomized controlled trial designed to compare nifedipine and enalapril in the management of postpartum hypertension. This is an equivalence study- meaning it is not expected one medication is better than the other. Nifedipine has been shown to be better than another common blood pressure medicine, labetalol, for postpartum hypertension but enalapril which is also used worldwide to manage blood pressure postpartum, has not yet been evaluated or compared to nifedipine. Investigators will identify and offer enrollment to women who are admitted for delivery with documented hypertension- participants with either chronic hypertension or pregnancy related hypertension will be included. Our hypothesis is both medications are safe and effective in managing blood pressure and preventing readmission for hypertensive complications during the postpartum period so evaluating the rate of readmission is the primary goal of the study. The only intervention of the trial will be to assign which medication the participant starts taking. Any decisions after that point- stopping medication, changing doses, additional medications, discharge from the hospital, etc, will all be at the discretion of the participant's primary provider.


Eligibility

Sex: FEMALEMin Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two blood pressure medications — nifedipine and enalapril — in women who develop high blood pressure during or right after pregnancy, to find out which works better and is safer after delivery. **You may be eligible if...** - You recently gave birth by vaginal delivery or C-section - You are at least 24 weeks pregnant at delivery - You have high blood pressure related to pregnancy, or had high blood pressure before pregnancy - Your blood pressure has reached 140/90 mmHg or higher on two occasions at least 4 hours apart - You speak English **You may NOT be eligible if...** - You have a medical reason you cannot take either nifedipine or enalapril - Your heart rate is consistently below 60 or above 110 beats per minute - Your primary language is not English Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGEnalapril 10mg QD

Enalapril 10mg PO QD will be given to manage postpartum hypertension. Duration of treatment to be dictated by primary provider.

DRUGNifedipine 30mg XL BID

Nifedipine 30mg XL BID will be given to manage postpartum hypertension. Duration of treatment to be dictated by primary provider.


Locations(1)

Methodist Women's Hospital

Omaha, Nebraska, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07023003


Related Trials