RecruitingNot ApplicableNCT07023640

Application of the CD73-Targeted Probe ⁶⁸Ga-DOTA-mPNE PET/CT Imaging in the Diagnosis of Malignant Tumors


Sponsor

Peking Union Medical College Hospital

Enrollment

50 participants

Start Date

Jul 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to perform ⁶⁸Ga-DOTA-mPNE PET/CT imaging in patients with clinically suspected or confirmed malignant tumors, in order to evaluate tracer uptake in lesions and analyze CD73 expression levels. In a subgroup of up to 10 participants, dynamic PET/CT imaging will be conducted for up to 90 minutes post-injection to assess the tracer's biodistribution and pharmacokinetic properties.Correlation analyses with relevant clinical indicators (such as pathology, immunohistochemistry, and molecular markers) will be carried out to further assess the diagnostic performance and clinical value of ⁶⁸Ga-DOTA-mPNE PET/CT in guiding tumor diagnosis and treatment. This study is expected to provide a novel molecular imaging tool for malignancies and offer clear, intuitive PET/CT-based evidence to support clinical diagnosis, differential diagnosis, and therapeutic decision-making.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new imaging scan using a radioactive probe (called 68Ga-DOTA-mPNE) to detect a protein called CD73, which may help doctors better diagnose and distinguish between different types of tumors using PET/CT imaging. **You may be eligible if...** - You are 18 or older with an expected survival of at least 12 weeks - You have not yet received radiation or chemotherapy - You are scheduled for surgery or a biopsy to confirm your diagnosis - You have at least one measurable tumor visible on imaging - You are willing to comply with follow-up requirements **You may NOT be eligible if...** - You have severe liver or kidney problems - You are pregnant, breastfeeding, or planning to conceive during the study - You are unable to lie flat for 30 minutes - You have claustrophobia or a psychiatric condition that prevents you from completing the scan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TEST68Ga-DOTA-mPNE

PET/CT examination was performed after intravenous injection of 68GA-DOTA-mPNE tracer


Locations(1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

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NCT07023640