A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort

This study is testing a new drug called AZD4248 to understand how it is processed by the body, how safe it is, and how it affects kidney function in healthy volunteers as well as patients with diabetic kidney disease (kidney damage caused by type 2 diabetes). **You may be eligible if...** - You are a healthy adult with suitable veins for blood draws - You have a BMI between 18 and 30 (or 20–35 if you have diabetic kidney disease) - For the patient group: you have been diagnosed with diabetic kidney disease - For the patient group: your HbA1c (blood sugar average) is 10.5% or below - For the patient group: you have been on a stable dose of ACE inhibitor or ARB blood pressure medication for at least 6 weeks **You may NOT be eligible if...** - You have other significant health conditions that could affect the study results - You do not meet the specific BMI or background criteria for your study group - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.