RecruitingNot ApplicableNCT07025720

Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk

Sponsor

University of California, Davis

Enrollment

25 participants

Start Date

Jul 1, 2025

Study Type

INTERVENTIONAL

Conditions

Suicidal Ideation Major Depressive Disorder (MDD)

Summary

The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts. We want to see if: 1. This treatment is feasible and acceptable to patients 2. It can reduce depression and suicidal thoughts 3. It can lower the chance of going to the hospital 4. It affects daily functioning (school, work, relationships) All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.

Eligibility

Min Age: 15 YearsMax Age: 25 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an intensive form of brain stimulation (called accelerated intermittent theta burst stimulation, or aiTBS) — a non-invasive treatment using magnetic pulses — for teenagers and young adults with major depression and suicidal thoughts. **You may be eligible if...** - You are between 15 and 25 years old - You speak English and can give informed consent - You were recently discharged from an emergency room or urgent care visit for suicidal ideation, or seen in a clinic for depression-related suicidal thoughts - You meet clinical criteria for major depressive disorder **You may NOT be eligible if...** - You are unable to give consent due to a medical condition, active psychosis, or substance use - You take benzodiazepines or other medications that would interfere with TMS treatment - You have active psychosis - You are pregnant or breastfeeding - You have metal implants or other contraindications to TMS or MRI - You participated in another clinical study in the past 30 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETMS

The protocol involves delivering sessions of intermittent theta burst stimulation (iTBS) of 60 cycles of 10 bursts of three pulses at 50 Hz were delivered in 2-second trains (5 Hz) with an 8-second intertrain interval. Stimulation sessions will be delivered hourly. Ten sessions will be applied per day (18,000 pulses/day) for 5 consecutive days (90,000 pulses in total). Stimulation will be delivered at 90% resting motor threshold (rMT).