Acute Treatment and Long-term Assessment of Adult Infectious Meningitis
Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Adults Meningitis
Hospital Israelita Albert Einstein
624 participants
Mar 30, 2026
OBSERVATIONAL
Conditions
Summary
Prospective, multicenter, observational clinical registry of adult patients with acute infectious meningitis across approximately 30 public and private hospitals in Brazil. The study will include adults, 18 years old and older, with suspected acute infectious meningitis. Data will be collected during hospitalization and post-discharge to evaluate clinical management, treatment and short and long-term outcomes. The study aims to generate real-world evidence on current practices and outcomes to support improvements in national care protocols.
Eligibility
Inclusion Criteria3
- Fever (axillary temperature ≥37.8°C) followed by two or more of the following symptoms: severe headache, vomiting, altered consciousness (confusion, drowsiness, or irritability), photophobia (increased sensitivity to light), presence of seizures OR
- Fever accompanied by at least one meningeal irritation sign, such as neck stiffness, Kernig's sign, or Brudzinski's sign OR
- Sudden onset of fever and appearance of petechial skin rash or hemorrhagic suffusions
Exclusion Criteria1
- \- Refusal to provide consent for study participation
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Locations(3)
View Full Details on ClinicalTrials.gov
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NCT07027475