This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Clearview Cancer Institute (Crestwood)

Huntsville, Alabama, United States

Clearview Cancer Institute

Huntsville, Alabama, United States

Ironwood Cancer & Research Centers

Chandler, Arizona, United States

Ironwood Cancer & Research Centers

Gilbert, Arizona, United States

Ironwood Cancer & Research Centers

Glendale, Arizona, United States

Ironwood Cancer & Research Centers

Goodyear, Arizona, United States

Ironwood Cancer & Research Centers

Mesa, Arizona, United States

Ironwood Cancer & Research Centers

Mesa, Arizona, United States

Ironwood Cancer & Research Centers

Phoenix, Arizona, United States

Ironwood Cancer & Research Centers

Scottsdale, Arizona, United States

Highlands Oncology Group, PA

Fayetteville, Arkansas, United States

Highlands Oncology Group, PA

Rogers, Arkansas, United States

Highlands Oncology Group, PA

Springdale, Arkansas, United States

UCLA Hematology/Oncology - Alhambra

Alhambra, California, United States

UCLA Hematology/Oncology - Atascadero

Atascadero, California, United States

Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location)

Beverly Hills, California, United States

Cedars-Sinai Cancer Beverly Hills

Beverly Hills, California, United States

UCLA Hematology/Oncology - Beverly Hills

Beverly Hills, California, United States

UCLA Hematology/Oncology - Burbank

Burbank, California, United States

UCLA Hematology/Oncology - Encino

Encino, California, United States

UCLA Hematology/Oncology - Irvine

Irvine, California, United States

UCLA Hematology/Oncology - Laguna Hills

Laguna Hills, California, United States

Cedars-Sinai Cancer at Cedars-Sinai Medical Center

Los Angeles, California, United States

Ronald Reagan UCLA Medical Center - Drug Information Center

Los Angeles, California, United States

UCLA Department of Medicine - Hematology/Oncology

Los Angeles, California, United States

UCLA Hematology/Oncology

Los Angeles, California, United States

UCLA Hematology/Oncology - Marina del Rey

Marina del Rey, California, United States

UCLA Hematology/Oncology - Pasadena

Pasadena, California, United States

UCLA Hematology/Oncology - Porter Ranch

Porter Ranch, California, United States

UCLA Hematology/Oncology - San Luis Obispo

San Luis Obispo, California, United States

UCLA Hematology/Oncology - Santa Barbara

Santa Barbara, California, United States

UCLA Hematology/Oncology- Santa Monica

Santa Monica, California, United States

UCLA Hematology/Oncology - Torrance

Torrance, California, United States

UCLA Hematology/Oncology - Santa Clarita

Valencia, California, United States

UCLA Hematology/Oncology - Ventura

Ventura, California, United States

UCLA Hematology/Oncology - Westlake

Westlake Village, California, United States

AdventHealth Medical Group Urology of Denver

Denver, Colorado, United States

Cancer Care Specialists of Illinois

Decatur, Illinois, United States

Cancer Care Specialists of Illinois

O'Fallon, Illinois, United States

MSK Basking Ridge

Basking Ridge, New Jersey, United States

MSK Monmouth

Middletown, New Jersey, United States

MSK Bergen

Montvale, New Jersey, United States

MSK Commack

Commack, New York, United States

MSKCC-Westchester (500 Westchester Ave.)

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (IDS Pharmacy)

Long Island City, New York, United States

Evelyn H. Lauder Breast and Imaging Center (BAIC).

New York, New York, United States

Memorial Sloan Kettering Cancer Center - Main Campus

New York, New York, United States

Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center

New York, New York, United States

University of Rochester Medical Center

Rochester, New York, United States

University of Rochester, Cancer Center Pharmacy (Investigational Product)

Rochester, New York, United States

Montefiore Einstein Comprehensive Cancer Center

The Bronx, New York, United States

Montefiore Medical Center- Montefiore Medical Park

The Bronx, New York, United States

MSK Nassau.

Uniondale, New York, United States

Duke Cancer Center Cary

Cary, North Carolina, United States

Duke University Medical Center (location of scans)

Durham, North Carolina, United States

Duke University Medical Center - Duke Cancer Center

Durham, North Carolina, United States

Duke University Medical Center - Duke University Hospital (location of scans)

Durham, North Carolina, United States

Duke University

Durham, North Carolina, United States

Duke Cancer Center Raleigh

Raleigh, North Carolina, United States

Duke Raleigh Hospital

Raleigh, North Carolina, United States

Duke Women's Cancer Care Raleigh (Pharmacy location and location of CT, MRI and Bone scan machines)

Raleigh, North Carolina, United States

University Hospitals Seidman Cancer Center at UH Avon Health Center

Avon, Ohio, United States

TriState Urologic Services PSC Inc. dba The Urology Group

Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

University Hospitals Seidman Cancer Center at UH Mentor Health Center

Mentor, Ohio, United States

UH Minoff Health Center at Chagrin Highlands

Orange, Ohio, United States

The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists

Lancaster, Pennsylvania, United States

Grand Strand Medical Center

Myrtle Beach, South Carolina, United States

Carolina Urologic Research Center, LLC

Myrtle Beach, South Carolina, United States

Parkway Surgery Center

Myrtle Beach, South Carolina, United States

The West Clinic, PLLC dba West Cancer Center

Germantown, Tennessee, United States

Urology Associates, P.C.

Nashville, Tennessee, United States

University of Texas Southwestern Medical Center - Simmons Cancer Center

Dallas, Texas, United States

University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital

Dallas, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Redbird

Dallas, Texas, United States

University of Texas Southwestern Medical Center-Zale Lipshy University Hospital

Dallas, Texas, United States

University of Texas Southwestern Medical Center

Dallas, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Fort Worth

Fort Worth, Texas, United States

US Oncology Investigational Product Center (IPC)

Irving, Texas, United States

University of Texas Southwestern Simmons Cancer Center - Richardson/Plano

Richardson, Texas, United States

Huntsman Cancer Institute

Salt Lake City, Utah, United States

Blue Ridge Cancer Care

Blacksburg, Virginia, United States

Blue Ridge Cancer Care

Low Moor, Virginia, United States

Blue Ridge Cancer Care

Roanoke, Virginia, United States

Blue Ridge Cancer Care

Salem, Virginia, United States

Blue Ridge Cancer Care

Wytheville, Virginia, United States

Northwest Medical Specialties, PLLC

Bonney Lake, Washington, United States

Northwest Medical Specialties, PLLC

Federal Way, Washington, United States

Northwest Medical Specialties, PLLC

Gig Harbor, Washington, United States

Northwest Medical Specialties, PLLC

Puyallup, Washington, United States

Northwest Medical Specialties, PLLC

Tacoma, Washington, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, United States

Asociación de Beneficencia Hospital Sirio Libanés

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

Centro de Investigación Pergamino

Pergamino, Buenos Aires, Argentina

Sanatorio Británico

Rosario, Santa Fe Province, Argentina

Instituto de Oncología de Rosario

Rosario, Santa Fe Province, Argentina

Centro Oncologico Korben

Buenos Aires, Argentina

Orange Health Service

Orange, New South Wales, Australia

Sydney Adventist Hospital

Wahroonga, New South Wales, Australia

Icon Cancer Centre Chermside

Chermside, Queensland, Australia

Mater Misericordiae Limited Mater Cancer Care Centre

South Brisbane, Queensland, Australia

ICON Cancer Centre - Kurralta Park

Kurralta Park, South Australia, Australia

Sir Charles Gairdner Hospital

Nedlands, Western Australia, Australia

ZAS Augustinus

Wilrijk, Antwerpen, Belgium

Institut Jules Bordet

Anderlecht, Bruxelles-capitale, Région de, Belgium

Jessa Ziekenhuis

Hasselt, Limburg, Belgium

AZ Maria Middelares

Ghent, Oost-vlaanderen, Belgium

AZ Sint-Lucas

Ghent, Oost-vlaanderen, Belgium

UZ Leuven

Leuven, Vlaams-brabant, Belgium

AZ Groeninge Campus Kennedylaan

Kortrijk, West-vlaanderen, Belgium

AZORG Campus Aalst-Moorselbaan

Aalst, Belgium

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará, Brazil

Hospital Erasto Gaertner

Curitiba, Paraná, Brazil

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa

Porto Alegre, Rio Grande do Sul, Brazil

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

Santo André, São Paulo, Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, São Paulo, Brazil

Centro de Estudos e Pesquisas Oncologia de Sorocaba (CEPOS)

Sorocaba, São Paulo, Brazil

Instituto do Cancer Arnaldo Vieira de Carvalho

São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino

São Paulo, Brazil

MBAL Uni Hospital

Panagyurishte, Pazardzhik, Bulgaria

Medical Center Futuremeds

Plovdiv, Bulgaria

Complex Oncology Center - Plovdiv EOOD

Plovdiv, Bulgaria

Prostate Cancer Centre

Calgary, Alberta, Canada

Centre of Applied Urology Research/Nova Scotia Health Authority

Halifax, Nova Scotia, Canada

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada

Lakeridge Health

Oshawa, Ontario, Canada

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre

Greenfield Park, Quebec, Canada

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, Canada

Jewish General Hospital

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus

Québec, Quebec, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer

Sherbrooke, Quebec, Canada

Diex Recherche Trois-Rivieres

Trois-Rivières, Quebec, Canada

Wannan Medical College Yijishan Hospital

Wuhu, Anhui, China

Peking University First Hospital

Beijing, Beijing Municipality, China

Beijing Friendship Hospital Affiliate of Capital University

Beijing, Beijing Municipality, China

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Chongqing University Cancer Hospital

Chongqing, Chongqing Municipality, China

Lanzhou university second hospital

Lanzhou, Gansu, China

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, China

Hunan Cancer Hospital

Changsha, Hunan, China

First Huai'an Hospital Affiliated to Nanjing Medical University

Huai'an, Jiangsu, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

Nanjing, Jiangsu, China

Nantong Tumor Hospital

Nantong, Jiangsu, China

The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

The First Hospital of China Medical University

Shenyang, Liaoning, China

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

Qilu Hospital of Shandong University

Jinan, Shandong, China

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Suining Central Hospital

Suining, Sichuan, China

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

The first affiliated hospital of Ningbo university

Ningbo, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

The Third Affiliated Hospital of Southern Medical University

Guangzhou, China

Masarykuv onkologicky ustav

Brno, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

Fakultni nemocnice Olomouc

Olomouc, Czechia

Urocentrum Praha s.r.o.

Prague, Czechia

Fakultni Thomayerova nemocnice

Prague, Czechia

Fakultni nemocnice v Motole

Prague, Czechia

Oulun yliopistollinen sairaala

Oulu, North Ostrobothnia, Finland

Kuopion Yliopistollinen Sairaala

Kuopio, Northern Savonia, Finland

Tampereen yliopistollinen sairaala

Tampere, Pirkanmaa, Finland

Vaasan Keskussairaala

Vaasa, Pohjanmaa, Finland

Turku University Hospital

Turku, Southwest Finland, Finland

Docrates Syöpäsairaala

Helsinki, Uusimaa, Finland

Centre Antoine-Lacassagne

Nice, Alpes-maritimes, France

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux, Aquitaine, France

Centre Leon Berard

Lyon Cedex08, Auvergne-Rhône-Alpes, France

Groupe Vivalto Santé - Clinique Pasteur-Lanroze

Brest, Brittany Region, France

CHU Besançon

Besançon, Doubs, France

Institut Godinot

Reims, Marne, France

Institut Jean Godinot

Reims, Marne, France

Centre Hospitalier de la Côte Basque

Bayonne, Pyrénées-atlantiques, France

Centre Hospitalier Lyon Sud

Pierre-Bénite, Rhône, France

Gustave Roussy

Villejuif, Val-de-marne, France

Institut de Cancérologie de l'Ouest

Angers, France

Henri Mondor Hospital

Créteil, Île-de-France Region, France

Heidelberg University Hospital

Heidelberg, Baden-Wurttemberg, Germany

Studienpraxis Urologie

Nürtingen, Baden-Wurttemberg, Germany

Universitaetsklinikum Ulm

Ulm, Baden-Wurttemberg, Germany

Universitaetsmedizin Goettingen

Göttingen, Lower Saxony, Germany

Urologie Neandertal - Praxis Mettmann

Mettmann, North Rhine-Westphalia, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus

Münster, North Rhine-Westphalia, Germany

Charité Universitaetsmedizin Berlin

Berlin, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Alexandra General Hospital of Athens

Athens, Attikí, Greece

General Hospital of Athens "G. Gennimatas"

Athens, Greece

Metropolitan Hospital

Athens, Greece

Athens Medical Center S.A -European Interbalkan Medical Center

Thessaloniki, Greece

Rabin Medical Center

Petah Tikva, Central District, Israel

Sheba Medical Center

Ramat Gan, Central District, Israel

Yitzhak Shamir Medical Center

Ẕerifin, Central District, Israel

Shaare Zedek Medical Center

Jerusalem, Jerusalem, Israel

Hadassah Medical Center

Jerusalem, Jerusalem, Israel

Rambam Health Care Campus

Haifa, Northern District, Israel

Sourasky Medical Center

Tel Aviv, TELL ABĪB, Israel

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

Meldola, Emilia-Romagna, Italy

Ospedale Santa Maria delle Croci

Ravenna, Emilia-Romagna, Italy

IRCCS Istituto Clinico Humanitas

Rozzano, Milano, Italy

Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, Piedmont, Italy

Istituto Nazionale Tumori Regina Elena

Rome, ROMA, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

Bologna, Italy

Ospedale San Raffaele

Milan, Italy

Azienda Ospedaliero Universitaria Maggiore della Carità

Novara, Italy

Istituto Oncologico Veneto IOV-IRCCS

Padova, Italy

ASUIT Trento - Santa Chiara Hospital

Trento, Italy

Centro Ricerche Cliniche di Verona

Verona, Italy

Chiba cancer center

Chiba, Chiba, Japan

National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime, Japan

National Hospital Organization Hokkaido Cancer Center

Sapporo, Hokkaido, Japan

Hokkaido University Hospital

Sapporo, Hokkaido, Japan

Kobe University Hospital

Kobe, Hyōgo, Japan

Kanazawa University Hospital

Kanazawa, Ishikawa-ken, Japan

Yokohama City University Medical Center

Yokohama, Kanagawa, Japan

Yokosuka Kyosai Hospital

Yokosuka, Kanagawa, Japan

The University of Osaka Hospital

Suita, Osaka, Japan

Keio university hospital

Shinjuku-ku, Tokyo, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan

National Hospital Organization Kumamoto Medical Center

Kumamoto, Japan

Osaka International Cancer Institute

Osaka, Japan

Yamagata University Hospital

Yamagata, Japan

Canisius-Wilhelmina Ziekenhuis

Nijmegen, Gelderland, Netherlands

Tergooiziekenhuizen, locatie Hilversum

Hilversum, North Holland, Netherlands

Reinier de Graaf Ziekenhuis, locatie Delft

Delft, South Holland, Netherlands

Tauranga Hospital

Tauranga, Bay of Plenty, New Zealand

Christchurch Hospital

Christchurch, Canterbury, New Zealand

Waikato Hospital

Hamilton, Waikato Region, New Zealand

Auckland City Hospital

Auckland, New Zealand

Palmerston North Hospital

Palmerston North, New Zealand

Clinical Research Center Spółka z ograniczoną odpowiedzialnością MEDIC-R Sp.k

Poznan, Greater Poland Voivodeship, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

Krakow, Lesser Poland Voivodeship, Poland

POLIMED CLINIC Sp. z o.o.

Wroclaw, Lower Silesian Voivodeship, Poland

Zachodniopomorskie Centrum Onkologii

Szczecin, West Pomeranian Voivodeship, Poland

Zachodniopomorskie Centrum Onkologii

Szczecin, Zachodniopomorskie Voivodeship, Poland

Szpitale Pomorskie Sp. z o.o.

Gdynia, Poland

Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie

Koszalin, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o .o.

Krakow, Poland

Clinical Best Solutions Sp. z o.o. S.K.

Lublin, Poland

Centrum Medyczne MEDYK

Rzeszów, Poland

EMC Instytut Medyczny S.A.

Wroclaw, Poland

Narodny onkologicky ustav

Bratislava, Slovakia

Vychodoslovensky onkologicky ustav, a.s.

Košice, Slovakia

MILAB, s.r.o., Urologicka ambulancia

Prešov, Slovakia

Privatna urologicka ambulancia, s.r.o.

Trenčín, Slovakia

Chonnam National University Hwasun Hospital

Hwasun-gun, Jeonranamdo, South Korea

National Cancer Center

Goyang-si, Kyǒnggi-do, South Korea

Seoul National University Bundang Hospital

Seongnam, Kyǒnggi-do, South Korea

Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea

Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [seoul], South Korea

Asan Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea

Samsung Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea

Ewha Womans University Mokdong Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea

Kyungpook National University Chilgok Hospital

Deagu, Taegu-kwangyǒkshi, South Korea

Chungnam national university hospital

Junggu, Taejǒn-kwangyǒkshi, South Korea

Parc de Salut Mar - Hospital del Mar

Barcelona, Barcelona [barcelona], Spain

Althaia, Xarxa Assistencial Universitària de Manresa

Manresa, Barcelona, Spain

Hospital Clínic de Barcelona

Barcelona, Catalunya [cataluña], Spain

Hospital Universitario Ramón y Cajal

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario 12 de Octubre

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario Virgen de la Victoria

Málaga, Málaga, Spain

CHUVI- Hospital Alvaro Cunqueiro

Vigo, Pontevedra [pontevedra], Spain

Fundación Instituto Valenciano de Oncología

Valencia, Valenciana, Comunitat, Spain

Hospital Clinico San Carlos

Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Spain

Hospital General Universitario de Valencia

Valencia, Spain

Inselspital Bern

Bern, Canton of Bern, Switzerland

Kantonsspital Winterthur

Winterthur, Switzerland

UniversitätsSpital Zürich

Zurich, Switzerland

Chang Gung Medical Foundation-Linkou Branch

Guishan Dist., Taoyuan, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

İ.A.Ü VM Medical Park Florya Hastanesi

Istanbul, İ̇stanbul, Turkey (Türkiye)

I.E.U. Medical Point Hastanesi

Izmir, İ̇zmir, Turkey (Türkiye)

Dokuz Eylul Universitesi Hastanesi

Izmir, İ̇zmir, Turkey (Türkiye)

Gulhane Egitim Arastirma Hastanesi

Ankara, Turkey (Türkiye)

Memorial Ankara Hastanesi

Ankara, Turkey (Türkiye)

Ankara University Health Practice and Research Hospitals

Ankara, Turkey (Türkiye)

Dicle Üniversitesi

Diyarbakır, Turkey (Türkiye)

Royal Blackburn Hospital

Blackburn, Blackburn WITH Darwen, United Kingdom

Velindre Cancer Centre

Cardiff, Cardiff [caerdydd Gb-crd], United Kingdom

Derriford Hospital

Plymouth, Devon, United Kingdom

Torbay Hospital

Torquay, Devon, United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital

London, Hammersmith and Fulham, United Kingdom

Royal Marsden Hospital (Chelsea)

London, Kensington and Chelsea, United Kingdom

Maidstone Hospital

Maidstone, KENT, United Kingdom

Guy's & St Thomas' NHS Foundation Trust

London, London, CITY of, United Kingdom

Western General Hospital

Edinburgh, Midlothian, United Kingdom

The Christie NHS Foundation Trust

Manchester, United Kingdom