RecruitingNCT07030153

Association of Genetic Variants With Myopia

Genetic Variants and Their Association With Myopia Risk, Progression, and Optimal Interventions in Children

Sponsor

Beijing Visionly Plus Eye Hospital

Enrollment

1,000 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Myopia

Summary

This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length). It will also examine how different treatments-such as low-dose atropine drops, orthokeratology lenses, specialized glasses, and increased outdoor time-interact with these genes. Finally, the research will develop a genetic risk score to help tailor personalized myopia prevention and treatment plans.

Eligibility

Min Age: 6 YearsMax Age: 18 Years

Inclusion Criteria3

Age 6-18 years.
Any Spherical equivalent refraction (SER)
Parental consent for genetic testing.

Exclusion Criteria3

Suspected genetic syndromes (e.g., Stickler, Marfan).
Other eye diseases (e.g., glaucoma, cataracts, retinal abnormalities, strabismus).
Prior refractive surgery

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Interventions

GENETICOral swab DNA analyzed for myopia-related gene variants

Beyond detecting links between gene variants and myopia development, the testing analyzes how these variants influence treatment effectiveness. The aim is to enable early risk prediction and personalized treatment guidance for children through oral DNA testing.