RecruitingPhase 1Phase 2NCT07030257

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

A Multi-Center, Open Label, Phase 1/2 Study of CP-383, in Patients With Advanced or Metastatic Solid Tumors


Sponsor

Tasca Therapeutics

Enrollment

150 participants

Start Date

Aug 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if an investigational drug CP-383 works to treat advanced cancer. It will also learn about the safety of CP-383. The main questions if aims to answer are: * Does CP-383 slow or stop the growth of cancer in patients with advanced cancer * What medical problems do participants have when taking CP-383 Researchers will test CP-383 in all kinds of cancers at various dose levels to determine what the best dose is to study further. Researchers will also see if certain cancers that have gene mutations respond better to CP-383 Participants will: * Take CP-383 every day by mouth until the researcher learns whether CP-383 is helping slow or reduce the cancer growth * Visit the clinic weekly for the first 6 weeks for checkups and tests * Visit the clinic every 3 weeks thereafter for checkups and tests


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is an early-phase study testing a new investigational drug called CP-383 in people with advanced or metastatic solid tumors (cancers that have spread and are no longer responding to standard treatments). **You may be eligible if:** - You have an advanced, recurrent, or metastatic solid tumor (not brain cancer) - Standard treatments are no longer working, are not available, or are not tolerable for you - You have measurable or detectable cancer on imaging - Tumor tissue is available for testing, or you are willing to have a biopsy - You are in good physical health and can carry out daily activities **You may NOT be eligible if:** - You have primary brain cancer (other solid tumors with brain metastases may be considered) - You have a serious active infection, autoimmune disease, or significant organ damage - You are pregnant or breastfeeding - You have received certain prior treatments that would interfere with this drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCP-383

Novel anti-cancer agent inhibiting pyrimidine synthesis in cancer cells


Locations(13)

Sarah Cannon Research Institute at HealthONE

Denver, Colorado, United States

Florida Cancer Specialists-Lake Nona

Orlando, Florida, United States

START Midwest

Grand Rapids, Michigan, United States

Washington University

St Louis, Missouri, United States

Nebraska Cancer Specialists

Omaha, Nebraska, United States

Carolina BioOncology Institute

Huntersville, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

Taylor Cancer Research Center

Maumee, Ohio, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

NEXT Oncology - Dallas

Dallas, Texas, United States

START San Antonio

San Antonio, Texas, United States

START Mountain Region

West Valley City, Utah, United States

NEXT Virginia

Fairfax, Virginia, United States

View Full Details on ClinicalTrials.gov

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NCT07030257


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