RecruitingEarly Phase 1NCT07030725

Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1

Targeted TRPM8 Stimulation and Brown Adipose Tissue Activation in Humans

Sponsor

Indiana University

Enrollment

24 participants

Start Date

Mar 27, 2025

Study Type

INTERVENTIONAL

Conditions

Regulation of Energy Expenditure

Summary

Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue activation contributes to this rise in the energy expenditure. The overall goal with this project is to determine whether topical menthol application stimulates brown adipose tissue.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Menthol Gel, a drug called Sham, and others for people with regulation of energy expenditure. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 40 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMenthol Gel

Menthol (5% L-menthol) will be applied to the anterior thorax.

DRUGSham

Sham gel applied to the anterior thorax.

BEHAVIORALTime control

No gel applied to anterior thorax.

Locations(1)

Indiana University

Bloomington, Indiana, United States

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NCT07030725