Reducing Systemic Inflammation in People on Antiretroviral Therapy

This study is testing whether a treatment can reduce persistent inflammation in people living with HIV who are on suppressive antiretroviral therapy (ART), which may lower their risk of heart disease and other complications. **You may be eligible if:** - You are living with HIV and are 40 or older, OR have lived with HIV for 25 or more years - Your HIV is undetectable (viral load under 50 copies/mL in the last 6 months) - You have at least one cardiovascular risk factor (such as high blood pressure, diabetes, smoking history, high cholesterol, or prior heart disease) - Lab tests show detectable levels of a specific inflammatory protein (sgp120) in the past year **You may NOT be eligible if:** - You have a known allergy to the study drug - You have severe liver disease or heart failure - You are pregnant or planning to become pregnant - You are taking certain medications (such as rifampicin, carbamazepine, or St. John's Wort) that interact with the study drug - You have a heart rhythm abnormality (prolonged QT interval) Talk to your doctor to see if this trial is right for you.