Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis
Therapeutic Effect of Combined Treatment of Oral Nutritional Supplement Based on Hyaluronic Acid With Hyaluronic Acid Intra-articular Injection on Symptomatic Knee Osteoarthritis
Taichung Veterans General Hospital
40 participants
Apr 21, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional supplement based on hyaluronic acid with hyaluronic acid intra-articular Injection on symptomatic knee osteoarthritis. Researchers will compare it to those who receive only hyaluronic acid injection to see if the combined treatment is better. Participants will receive a total of three months of oral hyaluronate or placebo agents.
Eligibility
Inclusion Criteria3
- Radiological evidence of osteoarthritis Ahlbäck stage I-III.
- Had knee effusion at the suprapatellar recess under ultrasonographic examination.
- Age between 60 and 75 years old.
Exclusion Criteria6
- Rheumatological disorders
- Accidental trauma or fractures involving knees in the past three months
- Neuropathic pain involving lower limbs
- Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders.
- Depression and cognitive problems
- Pregnancy
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Interventions
The patient receives oral hyaluronate and hyaluronate injection
The patient receives hyaluronate injection only
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07033312