Exercise in Hereditary ATTR (ATTRv) Amyloidosis
Effects of a 12-week Exercise Intervention on Physical and Mental Health in Hereditary ATTR (ATTRv) Amyloidosis
University of Maia
42 participants
Oct 1, 2024
INTERVENTIONAL
Conditions
Summary
This study aims to explore the effects of a 12-week exercise intervention on the physical and mental health of people living with Hereditary ATTR (ATTRv) Amyloidosis, a rare genetic disease caused by mutations in the transthyretin gene, leading to the deposition of amyloid fibrils in nerves and organs.
Eligibility
Inclusion Criteria4
- ATTRv Amyloidosis patients living in Portugal;
- Disease stage 1 or 2;
- No medical contraindication for exercising;
- Ability to provide informed consent.
Exclusion Criteria1
- \- Having undergone a liver transplant in the past 6 months.
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Interventions
The exercise sessions will have a frequency of 3 times a week and a duration of 60 minutes per session. Exercise intensity will be gradually increased throughout the program and will be monitored every session using Borg's Rated Perceived Exertion scale, aiming at levels of 12-13 ("fairly light to somewhat hard"). The program will be mainly composed of cardiorespiratory exercises and resistance exercises. It will also comprise flexibility exercises to improve joint range of motion and neuromotor exercises involving motor skills (balance, agility, coordination, gait...), proprioceptive training and multifaceted activities (tai ji, yoga...).
Locations(1)
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NCT07033715