A Randomized Controlled Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)
A Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia
West China Hospital
58 participants
Jun 25, 2025
INTERVENTIONAL
Conditions
Summary
This study is a single-center, double-blind, randomized controlled clinical trial with placebo as the control, aiming to evaluate the effectiveness of spermidine in preventing radiation-induced xerostomia during radiotherapy for head and neck tumors (including nasopharyngeal carcinoma).
Eligibility
Inclusion Criteria6
- Patients with histopathologically confirmed head and neck squamous cell carcinoma (including nasopharyngeal carcinoma).
- Aged ≥18 years and ≤80 years.
- ECOG performance status score ≤2.
- Receiving radical radiotherapy or concurrent chemoradiotherapy with radiation dose \>50 Gy, where: Both parotid glands receive an average dose ≥25 Gy; or one gland receives a dose ≥25 Gy and the other receives any dose.
- Blood routine parameters: hemoglobin ≥100 g/L, platelets ≥80×10⁹/L, white blood cell count ≥3.0×10⁹/L, absolute neutrophil count ≥1.5×10⁹/L.
- Signed informed consent form.
Exclusion Criteria9
- History of xerostomia, Sjögren's syndrome, or other known systemic diseases predisposing to dry mouth.
- Wheat allergy or gluten intolerance.
- Suspected or confirmed physical occlusion of bilateral salivary gland ducts.
- Prior history of head and neck radiotherapy.
- Use of any medications or herbal supplements that may affect salivary function within the past 30 days, or planned/final use during the study period (e.g., amifostine, cholinergic agonists \[pilocarpine, cevimeline\], certain β-adrenergic antagonists, anticholinergic drugs, or other known salivary function modifiers). If using saliva substitutes, patients must abstain from use for at least 24 hours prior to saliva and questionnaire data collection.
- Poor oral hygiene or severe periodontitis.
- Poor compliance.
- Pregnant or breastfeeding.
- Other patients deemed unsuitable by the investigator (e.g., concurrent severe comorbidities, mental disability, or severe emotional/psychiatric disorders).
Interventions
As a member of the polyamine family, spermidine is a trivalent cationic compound found in eukaryotic cells. It interacts with polyanions such as nucleic acids, proteins, and ATP through electrostatic binding, thereby maintaining genomic DNA stability, regulating gene transcription and translation, and modulating autophagy, apoptosis, oxidative stress, angiogenesis, and intercellular communication. Spermidine is indispensable for cell division and proliferation.
Patients in control group were treated with Spermidine simulants, and its use method and use time are the same as intervention group.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07035626