A Randomized Controlled Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma)

This study tests whether a supplement called spermidine can prevent or reduce dry mouth (called xerostomia) — a common and debilitating side effect of radiation therapy — in people being treated for head and neck cancer or nasopharyngeal carcinoma (a cancer at the back of the nose/throat). **You may be eligible if...** - You have a confirmed diagnosis of head and neck squamous cell carcinoma or nasopharyngeal carcinoma - You are between 18 and 80 years old - You are receiving radical radiotherapy or concurrent chemoradiotherapy with a radiation dose greater than 50 Gy - Your radiation plan means your salivary glands (parotid glands) will receive significant radiation - Your blood counts are within acceptable ranges **You may NOT be eligible if...** - You are not receiving the required level of radiation to the salivary glands - You have significant low blood counts - You have already developed severe dry mouth prior to treatment Talk to your doctor to see if this trial is right for you.