Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain
Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain : a Prospective Study With Long Term Follow up
Clinique du Sport, Bordeaux Mérignac
200 participants
Sep 11, 2025
INTERVENTIONAL
Conditions
Summary
The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications. This study aims to compare these two treatments over the long term (2 years).
Eligibility
Inclusion Criteria1
- Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).
Exclusion Criteria9
- Patients with infections,
- Patients who have had previous percutaneous corticosteroid injections,
- Patients undergoing systemic corticosteroid treatment,
- Patients with immune deficiencies,
- Patients who are allergic to the contrast medium used,
- Pregnant or breastfeeding patients,
- Patients with a history of allergies to anesthetics or corticosteroids,
- Anticoagulant treatment or blood disorders, patients on antiplatelet therapy
- Taking NSAIDs within two weeks prior to the procedure
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Interventions
Intervention consists of interlaminar CT guided epidural steroid injection
Intervention consists of interlaminar CT guided epidural platelet-rich plasma injection after recovery of plasma by blood sampling and centrifugation
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07036445