RecruitingPhase 1Phase 2NCT07038096

ZG006 and ZG005 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma

A Phase Ib/II Study of the Tolerability, Safety, Efficacy, and Pharmacokinetics of ZG006 in Combination With ZG005 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma(NEC)


Sponsor

Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Enrollment

350 participants

Start Date

Sep 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a randomized, multicenter, Phase Ib/II clinical trial, aimed at evaluating the efficacy and safety of the combination of ZG006 and ZG005 in patients with advanced small cell lung cancer and neuroendocrine carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests two investigational drugs — ZG006 and ZG005 — in patients with advanced small cell lung cancer or neuroendocrine carcinoma (a type of cancer that develops from hormone-producing cells), cancers that are difficult to treat after standard therapies fail. **You may be eligible if...** - You are between 18 and 70 years old - You have confirmed advanced small cell lung cancer or neuroendocrine carcinoma - Your cancer has progressed after standard treatment - Your general health is adequate for receiving treatment (ECOG performance status within range) **You may NOT be eligible if...** - You have uncontrolled brain metastases - You have serious heart, kidney, or liver problems - You have had certain prior immune checkpoint therapies Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGZG006

ZG006 will be administered as an intravenous (IV) infusion.

DRUGZG005

ZG005 will be administered as an intravenous (IV) infusion.


Locations(1)

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China

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NCT07038096


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