RecruitingNot ApplicableNCT07038733

Investigation of Lymph Node Biology in Kidney Cancer

Characterizing the Tumor-draining Lymph Nodes and Other Immune Sites in Renal Cell Carcinoma

Sponsor

Yale University

Enrollment

10 participants

Start Date

Jan 30, 2026

Study Type

INTERVENTIONAL

Conditions

Renal Cell Carcinoma (RCC)

Summary

The purpose of this pilot study is to investigate the phenotype, anti-tumor effector functions, and TCR repertoire of T cells isolated from patient tumor draining lymph nodes (TDLNs) to understand T cell priming and trafficking patterns in Renal Cell Carcinoma (RCC). Data and biospecimen collected will be used for current and future research projects involving the study of kidney cancer biology and related medical conditions. We will use this valuable resource to ask clinically relevant translational questions that pertain to biomarker discovery/validation, identification of novel therapeutic targets, and to better understand the genetic and biological basis of the various kidney cancers.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study collects tissue and lymph node samples from kidney cancer patients to better understand how the immune system and lymph nodes respond to kidney cancer, which may help develop better treatments in the future. **You may be eligible if...** - You are an adult with a known or suspected kidney cancer - You are being seen at Yale's urology, oncology, or nephrology departments - You are scheduled for surgery or another clinical procedure that involves removing tissue **You may NOT be eligible if...** - You are not having a procedure that would allow tissue collection - You are unable to provide informed consent - You have conditions that preclude participation in research studies Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREPeripheral Blood Sample for Immune Analysis

A peripheral blood sample will be collected at the time of surgery.

PROCEDURETumor Sample for Analysis

Extra tumor which is left over following clinical diagnoses will be collected.

PROCEDUREAdjacent non-malignant kidney for analysis

Extra normal tissue which is left over following clinical diagnoses will be collected.

PROCEDUREDraining lymph node(s) for analysis

Draining lymph nodes which have been identified by the surgeon visually, potentially using a tracer (injection of up to 5mg of ICG into the peritumor kidney) will be collected.

PROCEDURERegional non-draining lymph node(s) for analysis

Regional lymph nodes which have been deemed as non-draining by the surgeon will be collected.