A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.

This study is comparing two pre-surgery treatment approaches for patients with head and neck cancer that can be surgically removed. One group will receive low-dose radiation combined with targeted therapy and immunotherapy before surgery; the other group will receive targeted therapy and immunotherapy only. The goal is to see if adding a small dose of radiation helps shrink the tumor more before the operation. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with head and neck cancer (not nasopharyngeal carcinoma) that has been confirmed by biopsy - Your cancer has not spread to distant organs and is considered surgically removable - You are willing to undergo surgery after pre-treatment - You are in reasonably good physical condition (ECOG 0-1) - Your blood counts and organ function meet the required levels **You may NOT be eligible if...** - Your cancer has spread to other parts of the body - Your cancer is not surgically removable - You have significant organ dysfunction - You have previously received treatment for this cancer - You are not willing to have surgery Talk to your doctor to see if this trial is right for you.