Comparison of the Efficacy of Mesotherapy and Extracorporeal Shock Wave Therapy in Patients With Lateral Epicondylitis
Comparison of the Efficacy of Mesotherapy and Extracorporeal Shock Wave Therapy in Patients With Lateral Epicondylitis: A Prospective Randomised Controlled Trial
Haydarpasa Numune Training and Research Hospital
50 participants
Jul 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to investigate the efficacy of mesotherapy in patients with lateral epicondylitis and to determine whether it is as effective as extracorporeal shock wave therapy (ESWT). Is mesotherapy an effective method in patients with lateral epicondylitis? Researchers will compare Mesotherapy to extracorporeal shock wave therapy (ESWT) in patient with Lateral epicondylitis. Patients will be randomly assigned to either the Mesotherapy group or the ESWT group using a closed envelope method. * Group 1 (Mesotherapy group): Patients will receive a total of 5 sessions of mesotherapy, with one session every 7 days. * Group 2 (ESWT group): Patients will receive a total of 5 sessions of Extracorporeal Shock Wave Therapy (ESWT), with one session every 7 days. Patients will be assessed at three time points: before treatment, 30 minutes after the completion of the treatment, and 12 weeks after the completion of the treatment
Eligibility
Inclusion Criteria3
- Aged between 18 and 65 years
- Pain and tenderness in the unilateral lateral epicondyle for ≥6 weeks
- Clinically diagnosed with Lateral Epicondylitis
Exclusion Criteria13
- Receiving an interventional injection in the elbow region within the last 3 months
- Receiving physical therapy in the last 3 months
- Receiving regular nonsteroidal anti-inflammatory drug (NSAID) treatment in the last 2 weeks
- History of fracture or surgery in the affected elbow region
- Chronic inflammatory diseases
- Acute infection
- History of malignancy
- Coagulation disorders
- Pregnancy
- Presence of a pacemaker or electronic implants
- Cervical radiculopathy and entrapment neuropathy
- Drug allergies
- BMI > 35
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Interventions
For patients in Group 2, Extracorporeal Shock Wave Therapy will be applied to the lateral epicondyle area at 10-15 Hz frequency, 1.5-2.5 bar energy density, and 2000 pulses. Patients will receive a total of 5 sessions of Extracorporeal Shock Wave Therapy (ESWT), with one session every 7 days.
Intradermal mesotherapy involving lidocaine, pentoxifylline, meloxicam, and thiocolchicoside will be applied to painful elbow points using a 4 mm, 30G needle in a point-by-point technique at a 90° angle (0.1 cc per point). A nappage technique at a 45° angle will then be applied around the common extensor tendon. A total of five sessions will be administered, one every 7 days.
Locations(1)
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NCT07043335