A Clinical Trial Evaluating Injection of TQB6411 in Subjects With Advanced Malignant Tumors

Exclusion Criteria24

• Have appeared or are currently suffering from other malignant tumors;
• There are diseases that affect intravenous injection and intravenous blood collection;
• The adverse reactions of previous treatments failed to recover to CTCAE V5.0 grade score ≤1, except for toxicity without safety risk, such as grade 2 hair loss, grade 2 peripheral nerve toxicity, grade 2 anemia, non-clinical significance and asymptomatic grade 2 laboratory abnormalities, stable hypothyroidism with hormone replacement therapy;
• Those who have received major surgical treatment, obvious traumatic injury or major surgery during the expected study treatment within 4 weeks before the first medication (except for the surgery stipulated in the program), or have long-term uncured wounds or fractures;
• Subjects with any bleeding or bleeding events ≥CTC AE grade 3 within 4 weeks before the first dose;
• Arterial/venous thrombosis events occurred within 6 months before the first dose;
• People with active viral hepatitis and poor control;
• People infected with active syphilis who need treatment;
• There is a history of active tuberculosis, idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonia/radio-pneumonia that needs treatment, or active pneumonia with obvious clinical symptoms, and interstitial lung disease (ILD) that needs treatment, or currently associated with interstitial lung disease;
• Those with a history of abuse of psychotropic substances and cannot quit or have mental disorders;
• Preparing for or having previously received allogeneic bone marrow transplants or solid organ transplants;
• Have a history of hepatic brain disease;
• Suffering from major cardiovascular disease;
• Severe infection that is active or uncontrollable (≥CTC AE grade 2 infection);
• People who require hemodialysis or peritoneal dialysis if renal failure is required;
• Have a history of immunodeficiency, including HIV-positive or other acquired, congenital immunodeficiency diseases;
• Subjects who have poorly controlled autoimmune diseases and need to use immunosuppressive agents or systemic hormones to achieve immunosuppressive purposes and still need to continue using them within 7 days before the first dose (except for daily dose of glucocorticoid <10 mg prednisone or other therapeutic hormones);
• People with epilepsy and need treatment;
• Poor diabetes control \[fasting blood sugar (FBG) > 10mmol/L\];
• Tumor-related symptoms and treatment: subjects who have received chemotherapy, immunotherapy, small molecule targeted drugs, etc. within 3 weeks before the first dose, or are still in the 5 half-life of the drug; within 1 week before the first dose, they have received Chinese patent medicine treatment with anti-tumor indications in the National Medical Products Administration (NMPA) approved drug instructions; imaging (CT or MRI) shows that the tumor has invaded important blood vessels or the researchers judged that the tumor is very likely to invade important blood vessels during the subsequent study and causing fatal major bleeding; if it is not controlled, pleural effusion, pericardial effusion or moderate and severe ascites that still require repeated drainage; known to suffer from spinal cord compression, meningeal metastasis/cancer meningitis, accompanied by brain metastasis symptoms or symptoms/image control time is less than 4 weeks;
• Known allergies to research drugs or excipients;
• Have received previous treatment for Epidermal Growth Factor Receptor (EGFR)/c-Mesenchymal-epithelial transition dual anti-ADC drugs;
• Those who participated in and used other anti-tumor clinical trial drugs within 4 weeks before the first medication;
• According to the researcher's judgment, there are situations that seriously endanger the safety of the subject or affect the subject's completion of the study.