RecruitingPhase 1Phase 2NCT06877650

First-in-Human Investigation of JMT108 Injection in Participants With Advanced Malignant Tumors

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of JMT108 Injection in Participants With Advanced Malignant Tumors.


Sponsor

Shanghai JMT-Bio Inc.

Enrollment

436 participants

Start Date

Apr 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study is designed as an open-label, multi-center Phase 1 clinical study in participants with advanced malignant tumors to evaluate the safety, tolerability, PK characteristics, and preliminary anti-tumor activity of JMT108 injection, and to determine the RP2D/schedule for subsequent studies.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Ivonescimab, a drug called JMT108, and others for people with advanced malignant tumors. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGJMT108

Intravenous (IV) administration every three weeks (D1) in a 3-week cycle.

DRUGPembrolizumab

Intravenous (IV) administration every three weeks (D1) in a 3-week cycle.

DRUGIvonescimab

Intravenous (IV) administration every three weeks (D1) in a 3-week cycle.


Locations(1)

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

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NCT06877650


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