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RecruitingNCT07044089

Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery

Comparison of Individualized PEEP Application Versus Fixed PEEP Application for Lung-Protective Ventilation in Patients Undergoing On-Pump Coronary Artery Bypass Grafting Surgery

Sponsor

Kocaeli University

Enrollment

86 participants

Start Date

Jul 23, 2025

Study Type

OBSERVATIONAL

Conditions

Peep Titration in Lung Protective Ventilation

Summary

Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

  • Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
  • Patients between the ages of 18 and 70
  • ASA (American Society of Anesthesiologists) physical status classification II-III

Exclusion Criteria14

  • Patients with an ejection fraction below 35%
  • Patients who did not consent to participate in the study
  • Patients undergoing emergency surgery
  • Patients who are allergic to the anesthetic drugs used
  • Patients who have undergone lung resection
  • Those with a history of mechanical ventilation in the 2 months before surgery
  • Patients who have undergone total circulatory arrest and deep hypothermia
  • Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
  • Morbid obesity (Body Mass Index>35kg/m2)
  • Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
  • COPD (FEV1<70%)
  • Patients with chronic renal failure (serum creatine>1.8 mg/dl)
  • Anemia (Hg<10 gr/dl)
  • Patients who have had an intraaortic balloon pump placed.

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Locations(1)

Kocaeli University Faculty of Medicine

Kocaeli, izmit, Turkey (Türkiye)

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NCT07044089