NICardipine for Fast Achievement of Systolic BP Targets in ICH
NICardipine for Fast Achievement of Systolic BP Targets in ICH - a Quasi-randomized, Implementation Trial With Stepwise Rollout of Nicardipin Based Treatment of Hypertension.
Aarhus University Hospital
88 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
Quality improvement study with a quasi-randomized design. The study monitors the effect of a gradually implemented treatment algorithm prioritizing intravenous antihypertensives (e.g., nicardipine) over long-acting nitrate patches. It aims to increase the proportion of patients reaching target systolic BP \<140 mmHg within 1 hour of hospital admission while monitoring safety, clinical outcomes, and healthcare resource utilization.
Eligibility
Inclusion Criteria4
- Age ≥18 years
- Acute spontaneous Intracerberal Hemorrhage confirmed by imaging
- Symptom onset to stroke center admission <6 hours
- Elevated systolic blood pressure (>140 mmHg) at admission
Exclusion Criteria3
- Secondary causes of ICH (e.g., trauma, vascular malformation)
- Presumed fatal bleeding at admission
- Short remaining life expectancy (<12 month)
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Interventions
Nicardipine infusion based acute blood pressure lowering treatment
Glyceryltrinitrate based acute blood pressure lowering treatment
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07044232