RecruitingNCT07047482

Clinicopathological Value of p16 Expression in Colorectal Carcinoma

Clinicopathological Value of p16 Expression in Colorectal Carcinoma: An Immunohistochemical Study.

Sponsor

Sohag University

Enrollment

50 participants

Start Date

May 1, 2025

Study Type

OBSERVATIONAL

Conditions

Colorectal Carcinoma

Summary

Evaluation of the immunohistochemical expression of p16 in colorectal carcinoma and correlate its expression to different clinical and pathological parameters as patients' ages, sexes, tumor location, histopathological phenotype, status of nodal involvement, perineural and lymphovascular invasion.

Eligibility

Plain Language Summary

Simplified for easier understanding

This study is examining colorectal (colon and rectal) cancer tissue samples to see whether a protein called p16 is present and whether it has any relationship to how the cancer behaves or progresses. It is a laboratory-based study using already-collected tissue from patients who have had colorectal cancer surgery. **You may be eligible if...** - You have had colorectal cancer and tissue samples were collected during your treatment - Your tissue block has sufficient material for analysis - Complete clinical information is available in your medical record **You may NOT be eligible if...** - Your tissue sample is insufficient, damaged, or mostly dead (necrotic) tissue - Your medical records lack sufficient clinical data Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALImmunohistochemical staining

Immunohistochemical staining of paraffin embedded blocks of colorectal carcinoma tissues by p16 monoclonal antibodies to be evaluated with the positivity, intensity and distribution of the detected stain.