RecruitingNCT07047495

Personalization of External Beam Radiation Therapy in Localised Tumours

MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS


Sponsor

European Institute of Oncology

Enrollment

35 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing personalized external beam radiation therapy — where MRI imaging is used to better tailor and target radiation doses for people with early-stage prostate or breast cancer, aiming to deliver more precise radiation to the tumor while sparing healthy tissue. **You may be eligible if...** - You have early-stage localized prostate cancer (clinical stage T1-T2, no spread) OR early-stage breast cancer (unifocal ductal carcinoma, stage T1-T2 N0) - You are 18 or older with good general health (ECOG 0-2) - You have no contraindications to MRI - You are scheduled for active treatment (surgery, cryoablation, or radiotherapy) **You may NOT be eligible if...** - Your cancer has spread to lymph nodes or distant sites - You have had previous invasive cancer in the past 3 years - You have a mental disorder that prevents valid consent - For breast patients: you have bilateral breast cancer, a high-risk genetic mutation, or previously had chest radiation - For breast patients: you are male Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERprostate patient

patients with prostate cancer treated with RT at IEO

OTHERbreast patients

patients with breast cancer treated with RT at IEO


Locations(1)

European Institute of Oncology

Milan, Italy, Italy

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07047495


Related Trials