RecruitingNCT07047495

Personalization of External Beam Radiation Therapy in Localised Tumours

MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS

Sponsor

European Institute of Oncology

Enrollment

35 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Breast Adenocarcinoma Prostate Cancer (Adenocarcinoma)

Summary

The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Unifocal infiltrating ductal breast carcinoma, non-special histotype
clinical stage T1-T2,N0
No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.
Patients aged \>18 years
Good general condition (ECOG 0-2)
Expected active treatment (crioablation or surgery or radiotherapy ).

Exclusion Criteria16

Nodule involvement and metastasis (cN1 and/or cM1)
Concomitant inflammation of the intestine
Significant systemic diseases or ongoing oral anticoagulant therapy
Non-compliance of dose constraints in the treatment plan
Previous invasive cancer, unless the patient has had no disease for at least 3 years
Mental disorders that cannot ensure valid informed consent
Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma)
Male sex
High-risk mutation carrier patients
Bilateral breast cancer
synchronous distant metastases
Neoadjuvant therapy
autoimmune connective tissue diseases
previous radiotherapy to the chest
Mental disorders that cannot ensure valid informed consent
No previous thoracic radiotherapy