Ex Vivo Evaluation on Human Tissue of the Binding of Experimental Radiolabeled Ligands
Ex Vivo Evaluation of Experimental Radiolabeled Ligand Binding in Human Tissue Using Autohistoradiography HERO (Human Ex-vivo RadiOligand) Platform
Central Hospital, Nancy, France
300 participants
Nov 1, 2025
OBSERVATIONAL
Conditions
Summary
The HERO project aims to structure an ex vivo screening platform, based on anonymized human tissues, to early assess the tissue fixation of experimental ligands in an ethical, translational approach that complies with the principles of the 3Rs (Replacement, Reduction, Refinement).
Eligibility
Inclusion Criteria4
- Patients who underwent surgical resection at the Nancy University Hospital after 2019 (Information provided in the welcome booklet or on posters displayed in waiting rooms, mentioning the possible use of data or resection specimens, unless otherwise stated).
- No documented objection, in accordance with the MR004 methodology.
- Frozen human tissues (slides, blocks, or sections) from surgical resection or biopsy, transmitted by the CRB or the biopathology department.
- Samples are fully anonymized before being made available for analysis.
Exclusion Criteria3
- Unusable tissue (degraded, insufficient, contaminated, poorly preserved).
- Lack of traceability of the material.
- Explicit opposition from the patient to the use of their tissue for research.
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Interventions
Ex vivo evaluation of the binding of experimental radiolabeled ligands on human tissue using autohistoradiography
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07047677