RecruitingNot ApplicableNCT07048509

Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals

Sponsor

University of Ljubljana

Enrollment

45 participants

Start Date

Jun 24, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Prehypertension (Elevated Blood Pressure) or Hypertension

Summary

In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition. The study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how different exercise intensities affect blood vessel function right after a workout. Researchers want to know whether moderate-intensity or high-intensity interval training has a bigger short-term effect on blood pressure and blood vessel health — both in people with normal blood pressure and those with slightly elevated blood pressure (prehypertension). **You may be eligible if:** - You are between 18 and 50 years old - Your body mass index (BMI) is below 30 - You have normal blood pressure OR have been diagnosed with prehypertension by a doctor - You are mostly sedentary or only lightly active - You are not on any prescribed medication and have no chronic illnesses **You may NOT be eligible if:** - Your blood pressure is too low (hypotension) or too high (stage 2 hypertension, 140/90 or above) - You are highly physically active - You have any chronic disease - You have had a lower limb injury in the past 6 months - You are pregnant, breastfeeding, or have gone through menopause - You smoke - Your menstrual cycle is absent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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