Gynecological Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Adults
Gynecological and Fertility Impact of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia Diagnosed in Adulthood (GYNEGRAFT)
University Hospital, Bordeaux
80 participants
Sep 19, 2025
INTERVENTIONAL
Conditions
Summary
Gynecological impact and infertility are major issues for women after allogeneic hematopoietic stem cell transplantation. The aim of the present study is to investigate the prevalence of gynecological complications after allogeneic hematopoietic stem cell transplantation for acute leukemia in adulthood. By conducting a single-center retrospective descriptive analysis, the prevalence, follow-up and treatment of gynecological complications -including premature ovarian failure, vulvovaginal graft-versus-host-disease, cervical pathology- will be analysed
Eligibility
Inclusion Criteria5
- Women diagnosed with acute leukemia, who underwent allogeneic hematopoietic stem cell transplantation in adulthood (\>18 years),
- Aged 20 to 45 at the time of evaluation,
- At least 2 years post-transplant.
- French-speaking patients, without comprehension disorders, and literate,
- No objection to participation.
Exclusion Criteria2
- Premature ovarian failure prior to management of haemopathy, post-transplant relapse,
- Patient under legal protection
Interventions
A standardized questionnaire was specifically developed for the study to explore: * Women's socio-demographic data * Data about their hematological disease (type of leukemia, conditioning protocol, relapses, graft-versus-host disease etc.) * Information received by patients prior to transplantation concerning gynecological complications * Symptoms, screening, diagnosis and treatment of the main gynecological complications * Patients fertility (spontaneous or after assisted reproductive treatments)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07048730