Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

This study is testing ways to reduce graft-versus-host disease (GVHD) — a serious complication where donor immune cells attack the patient's body — after a bone marrow or stem cell transplant. It is for adults with leukemia or myelodysplastic syndrome (MDS) who need a transplant from a donor. **You may be eligible if...** - You have acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), or another related blood cancer - Your disease is in remission (less than 5% cancer cells in the marrow) - You are a good candidate for a high-intensity transplant that uses total body irradiation - A matched donor is available **You may NOT be eligible if...** - Your disease is not in sufficient remission - You are not medically fit for intensive conditioning (preparation) before transplant - You do not have an eligible donor Talk to your doctor to see if this trial is right for you.