RecruitingPhase 3NCT07050277

Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine


Sponsor

University of Toronto

Enrollment

50 participants

Start Date

Jun 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs. The multimodal approach, including single shot or continuous nerve blocks with catheters and spinal or epidural morphine, is a stablished strategy. Although the administration of intrathecal morphine (IM) has been shown to significantly reduce pain scores, it is not free of adverse effects. Postoperative urinary retention (POUR) is possible and might increase the risk of periprosthetic infection. The purpose of this study is to compare patients undergoing rTKAS under spinal anesthesia with IM to patients undergoing the same procedure, under the same anesthetic technique, but with no IM, for POUR and postoperative pain related outcomes. All patients will have single shot and continuous adductor canal block (CACB) and single shot IPACK (interspace between the popliteal artery and the posterior knee capsule) block. The hypothesis is that postoperative pain control is comparable between the groups, with lower incidence of POUR in patients with no IM given.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Intrathecal Morphine and a drug called No Intrathecal Morphine for people with anesthesia, spinal, arthroplasties, knee replacement, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIntrathecal Morphine

Intrathecal morphine

DRUGNo Intrathecal Morphine

No Intrathecal Morphine


Locations(1)

Mount Sinai Hospital

Toronto, Ontario, Canada

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NCT07050277


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