A Dose-Expansion Trial of Intravenous HNF4α srRNA for Unresectable or Metastatic Colorectal Cancer

This trial tests an experimental gene-based therapy called HNF4α srRNA, given by IV infusion, in people with colorectal cancer that cannot be surgically removed or has spread to other organs, and who have already tried standard treatments. **You may be eligible if:** - You are 18 or older and have colorectal cancer confirmed by biopsy - Your cancer is unresectable (cannot be surgically removed) or metastatic - You have already tried standard chemotherapy and/or targeted treatments, or cannot tolerate them - Your cancer is measurable on imaging scans - You have adequate blood counts and organ function - You have a life expectancy of at least 12 weeks - You are willing to use effective contraception **You may NOT be eligible if:** - You have brain metastases - You have a bowel obstruction, perforation, or active bleeding - You have severe kidney, liver, or heart disease - You have an active autoimmune disease or are on immunosuppressants - You have received anticancer treatment within the past 4 weeks - You are HIV positive, or have active hepatitis B or C - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.