PSMA PET Combined With MRI for the Detection of PCa

This study tests whether combining PSMA PET scan imaging (a specialized nuclear medicine scan that detects prostate cancer cells) with standard MRI improves the detection of clinically significant prostate cancer in men who have not yet had a prostate biopsy. **You may be eligible if:** - You are a male, 18 or older - You have clinical suspicion of prostate cancer (based on elevated PSA, abnormal prostate exam, certain MRI findings, or other risk factors) - You are scheduled for a template prostate biopsy - You have not been previously diagnosed with prostate cancer or received prostate cancer treatment - You are able to lie still for imaging scans **You may NOT be eligible if:** - You have already been treated for prostate cancer or have had a confirmed diagnosis - You have obvious spread of cancer seen on prior imaging - You have had another cancer in the past (except for certain skin cancers) - You have an active urinary tract infection or prostate infection - You have had prior pelvic radiation - You are unable or unwilling to undergo a prostate biopsy - You have a known allergy to the imaging agent used (68Ga-PSMA-11) Talk to your doctor to see if this trial is right for you.