CAR-T Cells Therapy for Patients With Autoimmune Diseases

This study tests a cutting-edge immune cell therapy called CAR-T cells — where your own immune cells are reprogrammed in the lab to fight disease — in people with severe autoimmune conditions like rheumatoid arthritis, lupus, Sjogren's syndrome, or systemic sclerosis that haven't responded well to standard treatments. **You may be eligible if...** - You are 18 or older - You have been diagnosed with rheumatoid arthritis, lupus (SLE), Sjogren's syndrome, or systemic sclerosis - Your disease is still active despite trying multiple standard medications - Your blood counts and organ function (liver, kidneys) meet minimum health requirements - You are not pregnant and agree to use contraception for at least 2 years after treatment **You may NOT be eligible if...** - You have a serious neurological condition (e.g., stroke, epilepsy, dementia) - You have significant heart disease - You have a history of cancer - You have an active or uncontrolled infection (including HIV, hepatitis B/C, tuberculosis) - You have had an organ or bone marrow transplant - You are currently pregnant or breastfeeding - You have end-stage kidney failure Talk to your doctor to see if this trial is right for you.