RecruitingPhase 2NCT07054567

A Study of BL-B01D1 + Pembrolizumab ± Bevacizumab in Patients With Recurrent or Metastatic Cervical Cancer and Endometrial Cancer

A Phase II Clinical Study to Evaluate the Efficacy and Safety of BL-B01D1 + Pembrolizumab Dual Therapy With or Without Bevacizumab (BL-B01D1 + Pembrolizumab ± Bevacizumab) in Patients With Recurrent or Metastatic Cervical Cancer and Endometrial Cancer


Sponsor

Sichuan Baili Pharmaceutical Co., Ltd.

Enrollment

96 participants

Start Date

Aug 21, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This Phase II study is a clinical trial to evaluate the efficacy and safety of BL-B01D1 + pembrolizumab dual therapy with or without bevacizumab (BL-B01D1 + pembrolizumab ± bevacizumab) in patients with recurrent or metastatic cervical cancer and endometrial cancer.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a combination of cancer-fighting drugs — BL-B01D1 (a targeted antibody-drug), pembrolizumab (an immunotherapy), and optionally bevacizumab (a drug that cuts off tumor blood supply) — in women with cervical cancer or endometrial (uterine) cancer that has come back or spread. **You may be eligible if...** - You are a woman aged 18–75 with cervical or endometrial cancer that has returned or spread - Your cancer has been confirmed by biopsy or cell testing - You have at least one measurable tumor - Your overall health is reasonably good (ECOG 0–1) - You have not been pregnant within 7 days of starting treatment and agree to use contraception during and for 6 months after treatment **You may NOT be eligible if...** - You have previously received certain targeted antibody-drug treatments for this cancer - You have active autoimmune disease or another active cancer - You have a serious heart, liver, or kidney condition - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBL-B01D1

Administration by intravenous infusion for a cycle of 3 weeks.

DRUGPembrolizumab

Administration by intravenous infusion for a cycle of 3 weeks.

DRUGBevacizumab

Administration for a cycle of 3 weeks.


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

View Full Details on ClinicalTrials.gov

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NCT07054567


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