Combination Vaccination and Broadly Neutralising Antibody Therapy in HIV

This trial tests a combination of an HIV vaccine and broadly neutralising antibodies (bNAbs) — powerful lab-made proteins that can attack many strains of HIV — in people living with HIV who are stable on antiretroviral therapy. The goal is to train and strengthen the immune system so it can potentially keep the virus suppressed if antiretroviral therapy is paused. **You may be eligible if...** - You are 18–64 years old and living with HIV - You have been on stable antiretroviral therapy for at least a year with an undetectable viral load - Your immune cell count (CD4) is above 500 or your CD4:CD8 ratio is greater than 1.0 - You are in otherwise good health with no major co-existing illnesses - You are on an integrase inhibitor or boosted protease inhibitor regimen **You may NOT be eligible if...** - Your HIV viral load has not been consistently suppressed - Your immune cell counts are too low - You have significant co-existing illnesses or are immunocompromised for other reasons - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.