RecruitingPhase 1Phase 2NCT07056790

Research on the Application of 68Ga-PSMA-CYC PET Imaging in the Diagnosis, Staging, and Restaging of Prostate Cancer


Sponsor

First Affiliated Hospital of Fujian Medical University

Enrollment

40 participants

Start Date

May 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

68Ga-PSMA-CYC is a novel radiotracer targeting PSMA. In this study, we investigated the safety, biodistribution, radiation dosimetry of 68Ga-PSMA-CYC PET/CT in patients with prostate cancer, and performed a head-to-head comparison with 68Ga-PSMA-617 and 68Ga-PSMA-11 to evaluate its diagnostic performance.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a new type of PET imaging scan — using a tracer called 68Ga-PSMA-CYC — to detect, stage, and monitor prostate cancer. The scan targets a protein (PSMA) found abundantly on prostate cancer cells, making it highly precise at finding cancer that may be missed by conventional imaging. **You may be eligible if...** - You have confirmed prostate cancer (either newly diagnosed or previously treated) - You are referred for imaging to help with diagnosis, staging, or monitoring for recurrence - You are able to give written consent **You may NOT be eligible if...** - You have a known allergy to PSMA-based tracers - You have a medical condition that, in the doctor's opinion, would significantly affect the imaging or your safety Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG68Ga-PSMA-CYC

Each prostate cancer patient underwent a 68Ga-PSMA-CYC (3-4 mCi) PET/CT scan, as well as a 68Ga-PSMA-617 (3-4 mCi) or 68Ga-PSMA-11 (3-4 mCi) PET/CT scan, with the time interval between the two scans not exceeding one week.

DRUGCYC

The dose will be 3-4mCi given intravenously.


Locations(1)

The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, China

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NCT07056790


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