RecruitingNCT07057362

Effect of Vitamin D Deficiency on the Frequency and Severity of Spinal Anesthesia-Induced Hypotension in Pregnant Women Undergoing Cesarean Section


Sponsor

Duzce University

Enrollment

140 participants

Start Date

Mar 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Spinal anesthesia-induced hypotension remains a common and significant complication during cesarean sections, posing risks for both mother and fetus. Vitamin D deficiency, frequently observed in pregnant women, is associated with altered vascular function and potential hemodynamic instability. This prospective observational study aims to investigate whether vitamin D deficiency is associated with an increased incidence and severity of spinal anesthesia-induced hypotension in pregnant women undergoing elective cesarean delivery. Vitamin D levels will be measured preoperatively, and intraoperative hemodynamic parameters will be closely monitored. The findings could contribute to improved management strategies for pregnant patients at risk of severe hypotension.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria3

  • Pregnant women aged 18 years or older
  • Scheduled for elective cesarean delivery under spinal anesthesia
  • Able and willing to provide written informed consent

Exclusion Criteria6

  • Emergency cesarean sections
  • History of significant cardiovascular disease (e.g., arrhythmia, heart failure)
  • Known neurological disorders affecting autonomic function
  • Current vitamin D supplementation within the past 30 days
  • Inability to undergo blood sampling or provide valid hemodynamic data
  • Contraindication to spinal anesthesia

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Interventions

OTHERIntraoperative Hemodynamic Monitoring

Continuous intraoperative monitoring of systolic blood pressure and heart rate following spinal anesthesia. Vasopressor usage and total fluid administration will be recorded.


Locations(1)

Duzce University Faculty of Medicine, Department of Anesthesiology and Reanimation

Düzce, Merkez, Turkey (Türkiye)

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NCT07057362


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