Hypersensitivity to Adrenomedullin in Post-Traumatic Headache
Hypersensitivity to Adrenomedullin in Post- Traumatic Headache: A Randomized Clinical Trial
Danish Headache Center
21 participants
Aug 1, 2025
INTERVENTIONAL
Conditions
Summary
Adrenomedullin is a neuropeptide implicated in the pathogenesis of headache. This study investigates whether adrenomedullin induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).
Eligibility
Plain Language Summary
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This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
The participants will receive continuous intravenous infusion of 20 mL of 19.9 pmol/kg/min adrenomedullin over 20 minutes.
The participants will receive a continuous intravenous infusion of 20 mL of placebo (isotonic saline) over 20 minutes.
Locations(1)
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NCT07059546