Bilateral Prefrontal and Insular TMS for Depression in Schizophrenia

This study is testing a specialized form of brain stimulation called transcranial magnetic stimulation (TMS) — delivered to two regions of the brain (the prefrontal cortex and the insula) — to treat depression in people with schizophrenia-spectrum disorders. TMS is a non-invasive procedure using magnetic pulses applied to the scalp. **You may be eligible if...** - You are between 18 and 60 years of age - You have been diagnosed with a schizophrenia-spectrum disorder - You score above a threshold on the Calgary Depression Scale for Schizophrenia, indicating significant depressive symptoms - You are able to provide written informed consent and understand the study **You may NOT be eligible if...** - You have metal implants in your head or a pacemaker (TMS safety concern) - You have a history of seizures or epilepsy - You have major medical illnesses that could affect brain stimulation safety - You are currently in an acute psychotic episode that prevents participation - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.