Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The Effect of Ketone Monoester Supplementation and High Altitude on Exercising Cerebral Blood Flow
McMaster University
14 participants
May 28, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
Eligibility
Inclusion Criteria1
- \- Must be a member of the research expedition team travelling to the Barcroft Research Station in White Mountain California
Exclusion Criteria6
- BMI \> 30
- No prescribed medications (oral contraceptives excluded)
- History of smoking
- Currently following a ketogenic diet or consuming exogenous ketogenic supplements
- History of heart, lung, blood vessel, or kidney disease
- Currently pregnant
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Interventions
0.6 g KME per kg body mass; \[R\]-3-hydroxybutyl \[R\]-3-hydroxybutyrate. (Delta G Ketone, TΔS, Oxford).
Inert, calorie-free placebo drink that is taste-matched to the ketone monoester supplement
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07063732