RecruitingNot ApplicableNCT07066566

The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing

The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing: A Randomised Cross-over Study


Sponsor

Larissa University Hospital

Enrollment

30 participants

Start Date

Apr 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing. Participants will : 1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed. 2. baseline characteristics will me monitored throughout the interventions 3. Esophageal pressure and minute ventilation will be monitored.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • age ≥18 years old
  • absence of symptoms and signs of respiratory failure (SpO2>95% at FiΟ2 0.21)

Exclusion Criteria4

  • pregnancy
  • SpO2<94% at FiΟ2 0.21
  • neuromuscular disease
  • contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, esophageal disease, nasal trauma, allergy to local lidocaine)

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Interventions

DEVICEAsymmetric nasal cannula - DUET

DUET asymmetric nasal high flow interface that fits best to patients' nostrils (size: one nostril of the patient should be fully occluded) Patients will be crossed - over between the 2 interventions

DEVICEConventional nasal high flow cannula

Well - established conventional nasal high flow cannula (size: medium) Patients will be cross - over between the 2 interventions


Locations(1)

University Hospital of Larissa, Department of Pulmonary Medicine

Larissa, Greece

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NCT07066566