RecruitingEarly Phase 1NCT07067905

Clinical Evaluation of [68Ga]Ga-XT771 PET for Diagnosis in Patients With Glioblastoma and Clear Cell Renal Cell Carcinoma


Sponsor

Chinese PLA General Hospital

Enrollment

15 participants

Start Date

Jun 27, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A prospective, open-label, phase 1 study. This clinical trial aims to evaluate the diagnostic value of 68Ga-XT771, a CAIX/CAXII protein-specific probe, in PET/CT imaging for patients with clear cell renal cell carcinoma and glioblastoma. Safety, tolerability, and biodistribution characteristics of 68Ga-XT771 will also be assessed.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a new PET scan imaging agent called [68Ga]Ga-XT771 — a radiotracer injected before imaging to highlight certain tumor cells — to see how accurately it can detect and visualize glioblastoma (an aggressive brain tumor) and clear cell renal cell carcinoma (a common type of kidney cancer) in patients. **You may be eligible if...** - You are 18 or older - You have been diagnosed with glioblastoma (a type of brain cancer) or clear cell renal cell carcinoma (a type of kidney cancer) - You have signed an informed consent form to participate **You may NOT be eligible if...** - You have a known allergy to any component of the imaging agent or similar compounds - You have a medical condition considered incompatible with the study procedures - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG68Ga-XT771

68Ga-XT771 is injected intravenously with a dose of 4-8 mCi


Locations(1)

Chinese PLA General Hospital

Beijing, China

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NCT07067905