Development and Validation of Metabolic Biomarkers for Early Diagnosis, Prognosis, and Recurrence of Colorectal Cancer：MetBio-CRC

This study (MetBio-CRC) is building and validating a set of blood and tissue-based markers (called metabolic biomarkers) that can help detect colorectal cancer earlier, predict how patients will do, and identify whether cancer has come back after treatment. Both people with colorectal cancer and healthy volunteers are needed. **You may be eligible if...** - You are 18 or older - You are either: a healthy adult willing to donate a blood sample, OR someone newly diagnosed with colorectal adenocarcinoma who has not started any anti-cancer treatment yet - You are willing to provide tissue and blood samples **You may NOT be eligible if...** - You have a known hereditary colorectal cancer syndrome (like Lynch syndrome or FAP) - You have diabetes, hypertension, chronic viral hepatitis, or inflammatory bowel disease that is hard to control - You have had another cancer in the past 5 years - You have taken antibiotics or probiotics in the past month - You are pregnant, breastfeeding, or planning to become pregnant Talk to your doctor to see if this trial is right for you.