DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7)
A Phase 1/2, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Efficacy of DZD6008 Combination Therapy in Patients With Locally Advanced or Metastatic NSCLC With EGFR Mutation (TIAN-SHAN7)
Dizal Pharmaceuticals
100 participants
Jul 16, 2025
INTERVENTIONAL
Summary
This study is designed to evaluate safety and antitumor activity of DZD6008 combination therapy in patients with advanced Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) mutations.
Eligibility
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Interventions
DZD6008 was administered orally at 40/60/90 mg QD.
Pemetrexed 500 mg/m2, every 3 weeks, intravenous infusion.
Carboplatin AUC 5 mg/mL/min, every 3 weeks, intravenous infusion.
Docetaxel 75 mg/m2, every 3 weeks, intravenous infusion.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07070440