RecruitingPhase 1NCT07070882
Oral Steroid Taper After Total Knee Arthroplasty
Effectiveness of an Oral Methylprednisolone Taper Following Primary Total Knee Arthroplasty
Sponsor
Columbia University
Enrollment
130 participants
Start Date
Jun 20, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Any patient undergoing primary TKA with a diagnosis of osteoarthritis
- > 18 years old
- Willingness to undergo randomization
- Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)
Exclusion Criteria14
- Reported chronic corticosteroid or opiate use prior to surgery
- Prior Open Surgery on the Ipsilateral Knee
- Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, septic arthritis, or postoperative traumatic arthritis
- American Society of Anesthesiologists (ASA) score ≥ 4
- Reported history of liver disease, renal disease, or diabetes mellitus
- Current systemic fungal infection or other local infection
- Immunocompromised or immunosuppressed
- Current peptic ulcer disease
- History of psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis
- Women with reported current pregnancy
- Known hypersensitivity to methylprednisolone
- ≤ 18 years old
- Inability to take oral medications
- Unable to provide consent
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGMethylprednisolone
Patients will receive a tapered dose of methylprednisolone with the standard of care pain management
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07070882
Related Trials
The Osteoarthritis Prevention Study
NCT059460444 locations
MOTION Clinical Trial
NCT068439809 locations
Serum Fetuin-A and COMP Levels in Knee Osteoarthritis
NCT077065691 location
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
NCT0750930781 locations
Analysis of the Pathophysiological and Functional State of the Knee Joint
NCT064907701 location