RecruitingPhase 1NCT07070882
Oral Steroid Taper After Total Knee Arthroplasty
Effectiveness of an Oral Methylprednisolone Taper Following Primary Total Knee Arthroplasty
Sponsor
Columbia University
Enrollment
130 participants
Start Date
Jun 20, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Any patient undergoing primary TKA with a diagnosis of osteoarthritis
- > 18 years old
- Willingness to undergo randomization
- Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)
Exclusion Criteria14
- Reported chronic corticosteroid or opiate use prior to surgery
- Prior Open Surgery on the Ipsilateral Knee
- Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, septic arthritis, or postoperative traumatic arthritis
- American Society of Anesthesiologists (ASA) score ≥ 4
- Reported history of liver disease, renal disease, or diabetes mellitus
- Current systemic fungal infection or other local infection
- Immunocompromised or immunosuppressed
- Current peptic ulcer disease
- History of psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis
- Women with reported current pregnancy
- Known hypersensitivity to methylprednisolone
- ≤ 18 years old
- Inability to take oral medications
- Unable to provide consent
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Interventions
DRUGMethylprednisolone
Patients will receive a tapered dose of methylprednisolone with the standard of care pain management
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07070882
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