RecruitingNCT07075874

Neutrophil to Lymphocyte Ratio and Postdural Headache

Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictor of Post-Dural Puncture Headache Following Cesarean Section Under Spinal Anesthesia

Sponsor

Istinye University

Enrollment

821 participants

Start Date

Jul 12, 2025

Study Type

OBSERVATIONAL

Conditions

Preoperative Neutrophil-to-Lymphocyte Ratio (NLR)

Summary

This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria6

Women aged 18 years or older
Underwent elective or emergency cesarean section under spinal anesthesia
Had complete preoperative complete blood count (CBC) data available
No known hematological or inflammatory disease
No intraoperative complications recorded
Medical records accessible for postoperative follow-up regarding PDPH symptoms

Exclusion Criteria5

Age under 18
Absence of preoperative complete blood count data
Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
Platelet count \<150,000/mm³ or INR \>1.5
Incomplete or missing medical records

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Interventions

OTHERPDPH

Observational analysis of preoperative inflammatory markers (e.g., NLR, PLR, SIRI) in relation to PDPH development following spinal anesthesia.

Locations(1)

Istinye Üniversity

Istanbul, Merkez Mahallesi, Turkey (Türkiye)

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NCT07075874