The Role of mGluR5 in CBT-I

This study is investigating whether a brain chemical receptor called mGluR5 plays a role in how cognitive behavioral therapy for insomnia (CBT-I) works in people with moderate-to-severe depression. **You may be eligible if...** - You are 18 years or older and in good physical health - You have been diagnosed with major depressive disorder (MDD) with a current depressive episode - Your depression is at least moderate in severity (MADRS score above 29) - Your sleep problems include difficulty falling asleep (sleep latency up to 128 minutes) - You are not currently taking effective antidepressant medication **You may NOT be eligible if...** - You have a history of psychosis - You have had drug or alcohol dependence in the past 6 months or abuse in the past 2 months - You have an unstable medical condition - You have used nicotine in the past year - You are currently taking medication known to affect glutamate levels in the brain - You have sleep disorders beyond insomnia Talk to your doctor to see if this trial is right for you.