The Effect of Dapagliflozin on Patients With Cardiomyopathy
May Mohamed Abdalla
100 participants
Aug 1, 2025
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial evaluates the efficacy and tolerability of early initiation of dapagliflozin in adult patients hospitalized with acute heart failure (AHF). The study aims to assess the effect of dapagliflozin on pulmonary congestion as measured by lung ultrasound (LUS), length of hospital stay, and cardiac and renal biomarkers. A total of 100 patients will be randomized into two groups: one receiving dapagliflozin plus diuretics and the other receiving diuretics alone. Key outcomes include the reduction of extravascular lung water (assessed by B-lines in LUS), improved diuretic response, changes in NT-proBNP, sST2, CA-125, and NGAL levels, and incidence of acute kidney injury. The study will be conducted at the Cardiology and ICU departments at Kasr Al Ainy Hospital, Cairo University
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Receives dapagliflozin 10 mg once daily + standard intravenous diuretic therapy
Arm B (Control Group): Receives standard intravenous diuretic therapy alone
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07076615