RecruitingPhase 4NCT07076615

The Effect of Dapagliflozin on Patients With Cardiomyopathy


Sponsor

May Mohamed Abdalla

Enrollment

100 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This randomized controlled trial evaluates the efficacy and tolerability of early initiation of dapagliflozin in adult patients hospitalized with acute heart failure (AHF). The study aims to assess the effect of dapagliflozin on pulmonary congestion as measured by lung ultrasound (LUS), length of hospital stay, and cardiac and renal biomarkers. A total of 100 patients will be randomized into two groups: one receiving dapagliflozin plus diuretics and the other receiving diuretics alone. Key outcomes include the reduction of extravascular lung water (assessed by B-lines in LUS), improved diuretic response, changes in NT-proBNP, sST2, CA-125, and NGAL levels, and incidence of acute kidney injury. The study will be conducted at the Cardiology and ICU departments at Kasr Al Ainy Hospital, Cairo University


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether dapagliflozin — a drug commonly used for diabetes and heart failure — can benefit patients hospitalized with acute heart failure, regardless of whether they have diabetes or what type of heart failure they have. **You may be eligible if...** - You are 18 years or older - You are hospitalized or visiting an emergency department for acute heart failure with typical symptoms - Your natriuretic peptide levels (a heart stress marker) are elevated - You are planned to receive intravenous diuretics (water pills) as part of your treatment **You may NOT be eligible if...** - You have type 1 diabetes - You have a urinary tract or genital infection - You are severely dehydrated (hypovolemia) - You have diabetic ketoacidosis - Your blood glucose is below 80 mg/dL or blood pressure is below 90 mmHg at enrollment - You have a known allergy to any SGLT2 inhibitor drug Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin (DAPA)

Receives dapagliflozin 10 mg once daily + standard intravenous diuretic therapy

DRUGDiuretic

Arm B (Control Group): Receives standard intravenous diuretic therapy alone


Locations(1)

Cairo University

Cairo, Egypt

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NCT07076615


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