Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
Impact of Serum Testosterone Level on Angiographic Complexity of Coronary Lesions in Premature Ischemic Egyptian Males
Sohag University
50 participants
Jan 1, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to investigate the association between serum testosterone levels and the angiographic complexity of coronary artery lesions in male patients under 45 years of age presenting with premature ischemic heart disease.
Eligibility
Inclusion Criteria3
- Male patients aged \<45 years.
- Diagnosed with premature ischemic heart disease.
- Undergoing elective coronary angiography for suspected coronary artery disease (CAD) .
Exclusion Criteria6
- History of acute coronary syndrome within the preceding 3 months.
- Prior diagnosis of hypogonadism or history of testosterone replacement therapy or anabolic steroid use.
- Active neoplasm or history of chemotherapy.
- Known hepatic cirrhosis, chronic kidney disease, or end-stage renal disease.
- Use of medications known to affect sex hormone levels (e.g., spironolactone, ketoconazole).
- Endocrine disorders such as sickle cell anemia or celiac disease.
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Interventions
All angiographic procedures will be performed. Coronary artery disease will be defined as \>70% stenosis in at least one major epicardial artery or \>50% the left main coronary artery.
The angiographic complexity of coronary artery disease (CAD) will be assessed using the SYNTAX score.
Locations(1)
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NCT07076771