Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity

This study is testing a precise form of post-surgery radiation therapy (stereotactic body radiotherapy, or SBRT) using adaptive technology — where the radiation is adjusted in real time — to reduce side effects in men with prostate cancer after surgical removal of the prostate. **You may be eligible if...** - You had your prostate surgically removed (radical prostatectomy) for localized prostate cancer - You meet at least one of these conditions after surgery: positive surgical margins, cancer extending beyond the prostate (pT3/pT4), Gleason score 8–10, rising PSA on two consecutive tests above 0.03 ng/mL, high-risk genomic score (Decipher), or cancer found in lymph nodes at time of surgery - A CT scan and MRI of your pelvis were done within 120 days before enrollment **You may NOT be eligible if...** - Your cancer has spread to distant sites - You have conditions that prevent safe radiation therapy - Required imaging has not been done within the required timeframe Talk to your doctor to see if this trial is right for you.